- The United States treatment service and Shengyuan international have learned that the combination of polypeptide and antibiotics may be the key to eliminate parasites causing leishmaniasis and avoid the toxicity of existing drugs to human and animals.
- Therefore, it is urgent to find new, effective and selective alternatives to leishmaniasis chemotherapy in order to reduce the adverse side effects of existing drugs such as baromycin and mitifloxin.
- The result is greater effectiveness, while reducing the number of oral drugs. In addition, the CPPs were not toxic to mammalian cells, but they had a role in Leishmania.
- Although DOX was not active in incubation with Leishmania in free state, because it could not penetrate the inside, DOX PPC coupling was toxic at very low concentration (≥ 1mm).
The United States treatment service and Shengyuan international have learned that the combination of polypeptide and antibiotics may be the key to eliminate parasites causing leishmaniasis and avoid the toxicity of existing drugs to human and animals.
The study, coordinated by researchers at the University Autonomous University of Barcelona, opens the door to a more effective new treatment against the disease.
Leishmaniasis is caused by protozoa leishmaniasis, which is transmitted by the bite of infected sandflies. Although the disease affects dogs primarily in rich countries, it can cause serious damage to human health in other countries, causing ulcers, bone marrow, liver or spleen damage, all of which can be fatal.
The World Health Organization estimates that more than 1billion people live in areas where the disease is endemic, with more than one million new cases per year.
Therefore, it is urgent to find new, effective and selective alternatives to leishmaniasis chemotherapy in order to reduce the adverse side effects of existing drugs such as baromycin and mitifloxin.
Rosa Maria ortuno and ona illa from the UAB Department of chemistry are responsible for coordinating a multidisciplinary study to find new anti lichmania therapy.
Jean Didier marechar, an organization lecturer who also participated in the study, was from the same department, lecturer ganny Nogues, cell biology of UAB, from phyisology and immunology, and the people’s Louis Rivas CIB Margarita Salas CSIC (Madrid) and milidim’s from iqac CSIC (Barcelona).
The study included the preparation and biological evaluation of new cell penetrating peptide (CPPS). CPPs can be used as a carrier or carrier of drugs to enter the cell membrane of parasites and release them in the internal, which leads to parasite death.
The result is greater effectiveness, while reducing the number of oral drugs. In addition, the CPPs were not toxic to mammalian cells, but they had a role in Leishmania.
Although the idea of CPPs for the treatment of leishmaniasis is not unknown, the importance of this study is its ability to penetrate cells and the selectivity of newly synthesized and studied peptides (mammalian cells vs parasite cells).
Rosa Maria otunno, lecturer, Department of chemistry, Barcelona Autonomous University
In particular, the study has been used to study peptides composed of nonprotein amino acids and DOX covalent conjugates, and adriamycin is also used in cancer treatment.
Although DOX was not active in incubation with Leishmania in free state, because it could not penetrate the inside, DOX PPC coupling was toxic at very low concentration (≥ 1mm).
Its cell penetration has been rationalized by molecular model research.
Ortuno concluded that the results are promising and “a lot of research is needed before considering new drugs, but we are now closer to our goals.”
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