Polypeptide generally refers to a type of single-chain compound formed by dehydration and condensation of 3-50 amino acids. It is between chemical agents and biological products and can be chemically synthesized.
Polypeptide drugs have many advantages-strong druggability, high activity, good specificity, relatively weak toxic reaction, not easy to accumulate, and less drug cross-reaction.
Human exploration of peptide drugs can be traced back to the beginning of the 20th century.
In 1921, a Canadian surgeon named Frederick Grant Banting succeeded in extracting insulin from the dog’s pancreas and injecting it into another dog who suffered from diabetes by removing the pancreas. , The latter’s excessively high blood glucose concentration drops rapidly.
Since then, the curtain of a century of using peptides to treat diseases has been slowly opened.
However, due to technical reasons and limitations such as low oral bioavailability of peptides and low plasma stability, the development of peptide drugs has almost stagnated for decades.
Until the 1980s, the commercial success of human insulin and synthetic gonadotropins produced by recombinant technology proved the feasibility of the peptide drug market and stimulated investment and research enthusiasm in this field.
In the first ten years of the 21st century, there were about 100 peptide drugs entering clinical trials every year, and in the last ten years, more than 400 peptide drugs entered clinical trials every year.
Peptide drugs ushered in an outbreak period.
Data show that as of May 2019, the number of peptide synthesis drugs in the world was 1,153, and there were 198 peptide drugs on the market in 2018. Among them, the anti-tumor field is the most, followed by genitourinary system and sex hormones, cardiovascular system drugs, etc.
Many peptide drugs have become a variety exceeding hundreds of millions of dollars in just one or two years after the market is on the market-Eli Lilly’s Du Yi Da (dulaglutide), which is indicated for diabetes, and has annual sales of 5.068 billion US dollars in 2020. Sales volume ranks first; Novo Nordisk’s two blockbuster products, Semaglutide and Liraglutide (for diabetes and weight loss drugs), have combined sales of approximately US$7.7 billion.
According to data from Evaluate pharma, the market size of orphan diseases/rare diseases, tumors, and diabetes in peptide drugs is more than 3 billion US dollars; there are also some heavy varieties in the digestive tract, orthopedics, immunology, and cardiovascular and cerebrovascular fields.
At the same time, research on new peptides and new drugs is still steadily proceeding. At present, there are more than 150 peptides in clinical development, and 400-600 peptides are undergoing preclinical research.
With the increase in investment and research in the field of peptides, peptide synthesis technology has become increasingly mature, and it is expected that the peptide therapeutic drug market will continue to maintain its growth momentum.
How many companies are there in peptide api manufacturer in china? The peptide api market is very promising, and the world is encouraging the development of peptide business. There is a peptide api list on the website Biofda.com, which contains various specifications of peptide APIs for customers to choose from. Shengnuo Technology is a peptide api manufacturer located in Chengdu, a city in southwest China. Not only peptide APIs, but also carnosine custom suppliers and cosmetic peptide suppliers
There are many peptide apis manufacture in China, but they are all small-scale companies. The China peptide company such as Sinotech is a leading company in China and has a very high position.
As a Chinese peptide company, Sinotech has been working silently, hoping to become a top peptide company in the world. There are many countries producing peptides in the world, such as bulk drug substance in India, gmp custom peptide in uk, and peptide production in usa. So what is polypeptide? What kind of peptide synthesis supplier should you choose? Follow our website: www.biofda.com, here will tell you the answer.