Polypeptide drugs are mainly used in the treatment of chronic diseases.
At present, peptide drugs are mainly distributed in seven major disease treatment fields, including rare diseases, cancer, diabetes, gastrointestinal tract, orthopedics, immunity, cardiovascular diseases, etc. among them, rare diseases, cancer and diabetes are the “troika” driving the market of polypeptide drugs.
There are also some representative varieties in the remaining four fields It includes liraglutide, dulaglycopeptide, somaluptide, leuprorelin, tripatide, octreotide, exenatide, etc. According to iqvia, in 2007, the global market size of peptide drug preparations was about 12.39 billion US dollars, which has increased to 34.05 billion US dollars by 2017, with an average annual compound growth rate of 11%.
Chart: global market size of peptide drug preparations
Source: Zhiyin capital
In terms of the varieties on the market, the product structure of China’s peptide drug market is significantly different from that of the international mature market. At present, the peptide drugs with large sales in China are mainly anti-tumor and immunomodulatory products. In developed countries in Europe and the United States, cancer, diabetes and rare diseases are the “three carriages” driving the market of peptide drugs.
The varieties with large sales volume are therapeutic drugs with clear clinical benefits, such as hypoglycemic drugs liraglutide and dulaglycopeptide, antitumor drugs leuprorelin and gol Serrelin, anti osteoporosis drug terlipatide, and grantirel for the treatment of recurrent multiple sclerosis. Compared with developed countries, the market share of polypeptide drugs for the treatment of diabetes and rare diseases in China is relatively small, and there is still a huge room for growth.
In recent years, with the continuous improvement of the overall strength of China’s pharmaceutical industry, the domestic peptide drug industry has also made considerable development. In the aspect of generic drugs, after the patent protection period of liraglutide and other global blockbuster peptide drugs has expired, many domestic enterprises have begun to invest a lot of resources to carry out imitation research, and some enterprises have applied to the State Food and Drug Administration for production.
Rapid development of polypeptide industry
At present, China has become a big exporting country of polypeptide API, accounting for more than 30% of the global peptide API market. Peptide enterprises, including Sinochem, Hanyu pharmaceutical and zhongpeptide Biochemical Co., Ltd., have entered the European and American markets through cGMP certification and DMF documents. Meanwhile, they have vigorously developed other markets, and their competitiveness has been continuously enhanced.
Chengdu shengnuo Biotechnology Co., Ltd
Chengdu Shengnuo Biotechnology Co., Ltd. was established in July 2001. It is a first-class peptide medicine industrial park with professional development, technology transfer, technical service, large-scale production and export of polypeptide drugs in China. The main products are octreotide acetate injection, thymopentin for injection; raw material drug products are bivalirudin, etibatide, liraglutide, etibante and octreotide.
Summary
At present, the research and development of innovative drugs in China is increasing day by day, and the pharmaceutical investment is also booming. The maturity of peptide synthesis technology and peptide drug design theory will enhance the international competitiveness of peptide innovative drug research and development in China, and will continue to promote the rapid development of polypeptide cdmo industry.
reference material:
[1] Zhou Binbin. Design, synthesis and application of functional peptides [D]. Central South University, 2013
[2] Hu Yuxi, Han Tianjiao, Hu Yanchen. Consideration of research and development and consistency evaluation of polypeptide generic drugs [J]. Chinese Journal of new drugs, 2020,29 (08): 875-880
[3] Chen Fangchao. Engineering design of peptide synthesis workshop [J]. Chemical engineering design communication, 2020,46 (03): 205-206
[4] Polypeptide drugs: Changpo and Houxue in investment. Zhiyin capital
[5] Ge Chang, Jiang Ling. Analysis of the application of polypeptide drugs [J]. Journal of clinical medicine, 2020,7 (32): 188
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Shengnuo Biotechnology is a high-tech China polypeptide manufacturers,who has over 19 years experience for the biotechnology .Our Products involve peptide raw materials,polypeptide drug.
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