Nature as a general bone graft material
Recently, Hideo Fushimi and others of Fuji company of Japan published the article “recombinant collagen polypeptide as a versatile bone graft biological” in the Journal of communications materials.
Abstract: autotransplantation and allogeneic transplantation are considered as the gold standard of transplantation.
However, in order to meet the growing demand of rapidly aging society, synthetic biomaterials will play an increasingly important role. Here, a biodegradable scaffold material is reported, which is made up of recombinant polypeptide based on human type I collagen alpha 1 chain (RCPhC1) and is the source of graft material based on hydrogel. It shows the flexibility of designing ideal bone graft characteristics.
The key internal isotropic pore structure is produced by the designed thin-layer freeze casting process. By adjusting the amino acid composition of rcphc1, the optimal biodegradation rate was controlled by dehydrogenation and crosslinking.
As a result, the rcphc1 bone graft produced by the highly scalable and simplified production protocol induced strong regeneration of mature bone tissue and was fully absorbed in preclinical animal models.
Recombinant human collagen peptide
Engineering factors affecting the dehydrogenation and crosslinking of rcphc1 to control biodegradation rate and mechanical strength.
To test the preclinical efficacy of optimized rcphc1 materials for bone transplantation in rodent and dog models.
reference
Fushimi, H., Hiratsuka, T., Okamura, A. et al. Recombinant collagen polypeptide as a versatile bone graft biomaterial. Commun Mater 1, 87 (2020). https://doi.org/10.1038/s43246-020-00089-9
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