- Many therapeutic targets in human diseases are mainly protein protein interaction (PPI), because most PPI It is difficult to block this type of interaction because small molecules can not be discharged from the body, and frequent accumulation of toxic metabolites in organs can lead to adverse reactions.
- Peptide compound is a kind of compound with amide bond, which can be divided into straight chain peptide compound and cyclic peptide compound.
- For sale, buy peptides, purchase peptides, and buy peptides online, you can find the Chinese peptide company:
Many therapeutic targets in human diseases are mainly protein protein interaction (PPI), because most PPI It is difficult to block this type of interaction because small molecules can not be discharged from the body, and frequent accumulation of toxic metabolites in organs can lead to adverse reactions.
On the contrary, protein drugs are composed of natural ingredients with low toxicity. Because they have more and stronger interaction with the target, they have precise specificity for the molecular target, so they have higher effect, so they have less adverse reactions. However, they usually have unstable metabolism, no oral bioavailability, poor membrane permeability, and can only target extracellular molecules, Moreover, the manufacturing cost is expensive, which leads people to seek alternative protein scaffolds as a source of new therapeutic agents.
Peptide compound is a kind of compound with amide bond, which can be divided into straight chain peptide compound and cyclic peptide compound.
In the 1940s, the first antimicrobial peptide, ramicidin s, was discovered.
In the past few decades, a large number of cyclic peptides with special structures have been isolated from plants, bacteria, fungi and marine organisms. Because of its high stability, special structure, rich activity and wide distribution, cyclopeptide has become a hot topic in drug development and research in recent years. Cyclopeptides are hyperstable peptides from plants. The three disulfide bonds that form cystine bonds and cyclization skeleton from head to tail are very stable. Compared with other peptides of similar size, the unique topological structure of cyclopeptides makes them extremely stable to chemical, thermal and biological degradation, and their excellent stability and tolerance to sequence substitution can make them used as a framework for drug design.
The natural function of cyclopeptides is considered as plant defense molecules, because they are widely expressed in plant tissues and have anti insect, nematode and mollusc activities. The abnormal stability of cyclopeptides has laid a foundation for its application in protein engineering and drug design. The application of cyclopeptides in pharmaceutical research can be divided into three categories according to whether the cyclopeptides have been replaced in structure and the degree of replacement: natural cyclopeptides, point mutation cyclopeptides, “grafting” cyclopeptides.
Naturally occurring cyclopeptides have many potential biological activities, including uterine contraction, hemolysis, antibacterial, anti HIV, anti-tumor activities and so on. Although natural cyclopeptides have the above extensive biological functions, some cyclopeptides have limited development potential in medical treatment due to their hemolytic effect. However, the minimal single point mutation of cyclopeptides does not affect their structural stability and biological activity, but also reduces their unwelcome hemolytic activity in pharmaceutical applications. Therefore, we explore a single amino acid The influence on the structural integrity and biological activity of cyclopeptides is very important to promote their application in protein engineering and pharmacy. As a therapeutic agent, cyclopeptide has the most promising application not only in the development of natural activity of cyclopeptide, but also in the local change of its original activity. On the basis of point mutation, cyclopeptide is highly resistant to sequence change, so that they can be used as a framework for molecular “grafting” with longer segments to produce new biology Active cyclic peptide.
Although linear bioactive peptides may have great potential, they are usually easy to be degraded by protease, so they may not be able to reach their target if they are administered throughout the body; on the contrary, incorporation of bioactive epitopes into cyclopeptide scaffolds can protect them from degradation. This process is also known as “grafting”, which refers to one or more natural peptide scaffolds replaced by a sequence of bioactive peptides Ring to form a ring heterozygote with “tailor-made” properties. Bioactive epitopes come from a wide range of sources, such as peptides (including natural or synthetic peptides), a peptide sequence (i.e. protein fragment) from a larger protein, or a peptide sequence based on a phage library. Generally, this kind of cyclopeptide scaffold should not have any unwelcome natural activity. For example, in most cases, grafting can remove the hemolytic activity of natural KB1, which is an important aspect of cyclopeptide used in the pharmaceutical field.
Cyclopeptides are a family of plant polypeptides that have been widely studied and are being accepted as potential drug design scaffolds. Although it has potential related to pharmacy, but because some cyclopeptides have different activities, such as the ideal inhibitory activity on the growth of cancer cells, often accompanied by the toxicity to normal cells, so far no cyclopeptides have entered the human clinical trial stage. However, the research in this field is still in its infancy, and the experimental results of cyclopeptides in animal models mean that this situation is likely to be realized in the near future. At present, the biggest challenge in this field is how to improve the oral bioavailability of cyclopeptides. Although some cyclopeptides have been proved to have oral activity, there are few literatures about the actual oral bioavailability, so it is expected that more quantitative research reports on these parameters will appear in the next few years.
For sale, buy peptides, purchase peptides, and buy peptides online, you can find the Chinese peptide company:
Shengnuo Biotechnology is a high-tech China polypeptide manufacturers,who has over 19 years experience for the biotechnology .Our Products involve peptide raw materials,polypeptide drug.
Our 0 defect has passed the FDA certification, and has become the first-class professional polypeptide drug and product development and large-scale production and export industry in China .
Our service scope：peptide synthesis、peptide hormones、peptide medicine、beauty peptide、peptide medicine product、peptide technology transfer、peptide technology service、peptide large-scale production、export of peptide
Thymopentin for Injection、 Thymalfasin for Injection 、 Bivalirudin 、Bulk Drug、 Liraglutide ……
How many companies are there in peptide api manufacturer in china? The peptide api market is very promising, and the world is encouraging the development of peptide business. There is a peptide api list on the website Biofda.com, which contains various specifications of peptide APIs for customers to choose from. Shengnuo Technology is a peptide api manufacturer located in Chengdu, a city in southwest China. Not only peptide APIs, but also carnosine custom suppliers and cosmetic peptide suppliers
are many peptide apis manufacture in China, but they are all small-scale companies. The China peptide company such as Sinotech is a leading company in China and has a very high position.
As a Chinese peptide company, Sinotech has been working silently, hoping to become a top peptide company in the world. There are many countries producing peptides in the world, such as bulk drug substance in India, gmp custom peptide in uk, and peptide production in usa. So what is polypeptide? What kind of peptide synthesis supplier should you choose? Follow our website: www.biofda.com, here will tell you the answer.