- Small timber research
- In this paper, the TFP derivatives were prepared and applied to the innovation and green process of LPPS. At the same time, the new uses of organic phosphorus were revealed. The results showed that:
- For sale, buy peptides, purchase peptides, and buy peptides online, you can find the Chinese peptide company:
Small timber research
Release time: 08-1910:32 students
Recently, the research paper “liquid phase total synthesis of plecanatide aided by diphenylphosphinyloxyl diphenyl ketone (DDK) derivatives” independently completed by Professor Qin Chuanguang of Northwestern Polytechnic University has been officially published online by organic letters, the top journal in the first area of chemical discipline. The first author of this paper is Li Haidi, a doctoral student. The school of chemistry and chemical engineering of Northwest Polytechnic University is an independent unit.
In this paper, we developed a new type of small organophosphorus molecule as a green peptide synthesis carrier (GPS), and successfully realized the liquid phase total synthesis of plecanatide (trade name: trulance). Procanatide, an oral guanylate cyclase C (GC-C) agonist developed by synergy pharmaceuticals, was first approved by FDA in the United States on January 19, 2017 for the treatment of gastrointestinal diseases, such as irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC). At present, as a candidate drug, the third phase clinical efficacy trial of IBS-C indication is being carried out.
Compared with the traditional resin solid-phase peptide synthesis method, this paper proposed a better resin free synthesis strategy to synthesize long-chain bicyclic pukanatide, and verified that the target product can be synthesized in a resin free way on organophosphorus small molecule carriers by adjusting and optimizing DDK derivatives.
It is worth mentioning that without chromatographic separation, the use of carrier assisted precipitation (SAP) technology omits the procedures of intermediate purification in the peptide synthesis process, significantly simplifies the cumbersome steps of peptide synthesis, improves the feasibility and efficiency of the reaction, and significantly avoids the excessive use of solvents and raw materials (such as N-terminal protected amino acids, coupling agents, deproteinization) Protective agent, etc.).
In addition, DDK derivatives were used as atom economical, simple and green small molecule carriers, which creatively reduced PMI, one of the most basic and valuable indicators in green chemistry of peptide synthesis. DDK derivative carrier has the characteristics of convenient synthesis and high yield, which is suitable for large-scale production, and can be recycled and reused after peptide synthesis.
Therefore, compared with the traditional peptide synthesis method, the production cost and pollution waste of this method will be greatly reduced, thus realizing a more green and large-scale peptide production. Obviously, this method can also be widely used in the field of simplified synthesis of other peptide drugs and biomaterials, and promote scientific research and industrial production.
(2) In the Journal of chemistry, org. Lett. (2020, After the publication of relevant achievements by org. Chem. Front. (2020, 7:689-696), the research paper “synthesis of tri (4-formylphenyl) phosphate derivatives as recyclable triple equivalent supports of peptide synthesis” has been published by the Journal of organic, a famous top journal in the field of chemistry Chemistry was officially published online. The first author of this paper is Li Haidi, a doctoral student, with the school of chemistry and chemical engineering of Northwest Polytechnic University as an independent unit.
In order to find new applications of organophosphorus compounds, tri (4-formylphenyl) phosphonate (TFP) derivatives (such as alcohols, oximes and halogenates) were successfully synthesized and used as C-terminal protecting group or green trivalent carrier of amino acids in liquid phase peptide synthesis (LPPS).
Because of the carrier assisted precipitation (SAP) of TFP derivatives, peptide intermediates in peptide synthesis can be collected by rapid precipitation and simple filtration without chromatographic purification. In addition, the TFP derivative carrier can be directly recycled without further regeneration after being cut off from the target peptide.
In this paper, the TFP derivatives were prepared and applied to the innovation and green process of LPPS. At the same time, the new uses of organic phosphorus were revealed. The results showed that:
(1) TFP derivative carrier had C-terminal protection on amino acid synthetic peptide.
(2) TFP derivatives have excellent precipitation properties, which help to purify GPS linked peptide intermediates in peptide synthesis. The final target peptide can be easily separated and purified by simple precipitation without using preparative HPLC which requires a lot of solvent and time. It is worth noting that the method they developed can be applied to convenient large-scale peptide synthesis.
(3) The coupling reaction in homogeneous solution mediated by TFP derivatives can avoid excessive use of amino acids, greatly reduce the waste of raw materials and effectively reduce the cost.
(4) TFP derivative carrier is easy to synthesize and can be directly recycled after cleavage from the target peptide without further regeneration, which greatly reduces waste discharge and cost consumption. Due to the three reaction sites on each small molecule carrier, the atom utilization of the carrier is greatly improved compared with the traditional low loading SPPs.
Through the sap effect of TFP derivatives, the large-scale synthesis of peptides can be realized more economically and environmentally. The application of organophosphorus molecules will provide new synthetic tools for the scientific research and industrial production of peptide chemicals, peptide drugs and peptide based biomedical materials.
The research group has independently opened up a new field of green and large-scale synthesis of peptides, and has made remarkable scientific and technological progress and achievements. Recently, it has been listed in the top journals of chemistry, organic letters, The Journal of organic chemistry and organic chemistry frontiers) They have published a series of academic papers with northwest Polytechnic University as an independent unit in famous international journals, which indicates that their research work has been highly affirmed and recognized by international peers in the field;
at present, they have applied for 8 invention patents; at the same time, their research results have also attracted the attention and favor of entrepreneurs in relevant industries, and have been awarded Hubei xinshengyuan bioengineering Ltd. horizontal contract funding, plans to long-term cooperation research and development of related technical products.
This will provide sufficient and stable research direction, scientific research foundation, technical reserves and financial support for the recruitment and training of doctoral students in the future.
This paper is supported by the general program of National Natural Science Foundation of China, international cooperation and exchange program of the Ministry of science and technology of the people’s Republic of China, national innovation and entrepreneurship training program for college students, key project of basic research program of natural science of Shaanxi Province, international academic exchange support program of Northwest Polytechnic University and peak experience program of college students.
Source: Northwest Polytechnic University
For sale, buy peptides, purchase peptides, and buy peptides online, you can find the Chinese peptide company:
Shengnuo Biotechnology is a high-tech China polypeptide manufacturers,who has over 19 years experience for the biotechnology .Our Products involve peptide raw materials,polypeptide drug.
Our 0 defect has passed the FDA certification, and has become the first-class professional polypeptide drug and product development and large-scale production and export industry in China .
Our service scope：peptide synthesis、peptide hormones、peptide medicine、beauty peptide、peptide medicine product、peptide technology transfer、peptide technology service、peptide large-scale production、export of peptide
Thymopentin for Injection、 Thymalfasin for Injection 、 Bivalirudin 、Bulk Drug、 Liraglutide ……
How many companies are there in peptide api manufacturer in china? The peptide api market is very promising, and the world is encouraging the development of peptide business. There is a peptide api list on the website Biofda.com, which contains various specifications of peptide APIs for customers to choose from. Shengnuo Technology is a peptide api manufacturer located in Chengdu, a city in southwest China. Not only peptide APIs, but also carnosine custom suppliers and cosmetic peptide suppliers
are many peptide apis manufacture in China, but they are all small-scale companies. The China peptide company such as Sinotech is a leading company in China and has a very high position.
As a Chinese peptide company, Sinotech has been working silently, hoping to become a top peptide company in the world. There are many countries producing peptides in the world, such as bulk drug substance in India, gmp custom peptide in uk, and peptide production in usa. So what is polypeptide? What kind of peptide synthesis supplier should you choose? Follow our website: www.biofda.com, here will tell you the answer.