Chengdu Kaijie bio medicine Peptide API
GHRP-6 Acetate Product description
GHRP-6 is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor.
It inhibits binding of the GHS-R agonist MK-0677 (ibutamoren; Item No. 18003) to COS-7 cell membranes expressing human GHS-R type Ia (Ki = 1.9 nM) and binding of ghrelin to COS-7 cells expressing human GHS-R (Kd = 260 nM).
GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor (EC50 = 4.5 nM) and inositol phosphate production in COS-7 cells expressing the human receptor (EC50 = 0.83 nM). It also acts as a negative allosteric modulator of ghrelin (Item Nos. 15072 | 24458) signaling.
GHRP-6 (0.03 μg/ml) induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland.
It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.
GHRP-6 Acetate Chemical Properties
| Formal Name |
| L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide, triacetate |
| CAS Number |
| 145177-42-0 |
| Synonyms |
| Growth Hormone Releasing Peptide 6 |
| Hexapeptide-2 |
| HWAWFK-NH2 |
| SKF 110679 |
| U 75799E |
| Molecular Formula |
| C46H56N12O6 • 3C2H4O2 |
| Formula Weight |
| 1053.2 |
| Purity |
| ≥98% |
| Formulation |
| A crystalline solid |
| λmax |
| 221 nm |
| SMILES |
| O=C(N[C@H](CC1=CC=CC=C1)C(N[C@H](C(N)=O)CCCCN)=O)[C@@H](NC([C@H](C)NC([C@H](NC([C@H](CC2=CN=CN2)N)=O)CC3=CNC4=C3C=CC=C4)=O)=O)CC5=CNC6=C5C=CC=C6.CC(O)=O.CC(O)=O.CC(O)=O |
| InChi Code |
| InChI=1S/C46H56N12O6.3C2H4O2/c1-27(54-44(62)39(20-29-23-51-35-15-7-5-13-32(29)35)57-43(61)34(48)22-31-25-50-26-53-31)42(60)56-40(21-30-24-52-36-16-8-6-14-33(30)36)46(64)58-38(19-28-11-3-2-4-12-28)45(63)55-37(41(49)59)17-9-10-18-47;3*1-2(3)4/h2-8,11-16,23-27,34,37-40,51-52H,9-10,17-22,47-48H2,1H3,(H2,49,59)(H,50,53)(H,54,62)(H,55,63)(H,56,60)(H,57,61)(H,58,64);3*1H3,(H,3,4)/t27-,34-,37-,38+,39+,40-;;;/m0…/s1 |
| InChi Key |
| XGWOPQAMQAZCJE-SLBOMMQWSA-N |
| Shipping & Storage Information |
| Storage |
| -20°C |
| Shipping |
| Room Temperature in continental US; may vary elsewhere |
| Stability |
| ≥ 2 years |
Polypeptide Production Specifications
| CAS Registry Number | 128270-60-0 |
|---|---|
| Categories | APIsPeptides; Biopharmaceuticals |
| Sales markets | Western Europe; Asia; North America; Central/South America |
| Supplied from | China |
| Selling Points | International Approvals/Standards |
CPhIonline Consultation details
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