Semaglutide (trade names Rybelsus, Ozempic) is a medication used for the treatment of type 2 diabetes.[1][2]

Semaglutide acts like human glucagon-like peptide-1 (GLP-1) so that it increases insulin secretion, thereby increasing sugar metabolism. It is distributed as a metered subcutaneous injection in a prefilled pen. One of its advantages over other antidiabetic drugs is that it has a long duration of action, thus, only once-a-week injection is sufficient.[3]

An injection version was approved in 2017 in the United States, and in Europe, Canada, and Japan in 2018. A version which is taken by mouth was approved in 2019 in the United States. It is the first glucagon-like peptide (GLP-1) receptor protein treatment approved for use in the United States that does not need to be injected.[4] It was developed by the Danish company Novo Nordisk.

Side effects including nausea, vomiting, diarrhea, abdominal pain, and constipation may occur.[5]

    Semaglutide Specifications

    Synthesis modechemic synthesis,solid phase synthesis
    CategoriesAPIsPeptides; Biopharmaceuticals
    Sales marketsWestern Europe; Asia; North America; Central/South America
    Supplied fromChina
    Selling PointsInternational Approvals/Standards

    Show more specifications

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    SemaglutideBefore the end of 2022

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