CAS No.: 62304-98-7
Molecular formula: c129h215n33o55
English synonym: thymalfasin[ USAN:INN ]; Thymalfasin;
N-Acetyl-L-seryl-L-alpha-aspartyl-L-alanyl-L-alanyl-L-valyl-L-alpha-aspartyl-L-threonyl-L-seryl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-alpha-glutamyl-L-lysyl-L-lysyl-L-alpha-glutamyl-L-valyl-L-valyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-alpha-glutamyl-L-asparagine; Thymosin alpha1 （human）;
Thymosin alpha1 （ox）;
Thymosin alpha1 （cattle）;
Thymosin alpha 1
Molecular weight: 3108.2755
Sequence: AC ser ASP ala ala Val ASP thr ser ser ser Glu ile thr thr Lys ASP Leu Lys Glu Lys Glu Val Val Glu ala Glu ASN oh
Thymosin α1 is a peptide fragment derived from prothymosin alpha, a protein that in humans is encoded by the PTMA gene.
It was the first of the peptides from Thymosin Fraction 5 to be completely sequenced and synthesized. Unlike β thymosins, to which it is genetically and chemically unrelated, thymosin α1 is produced as a 28-amino acid fragment, from a longer, 113-amino acid precursor, prothymosin α.
Thymosin α1 is believed to be a major component of Thymosin Fraction 5 responsible for the activity of that preparation in restoring immune function in animals lacking thymus glands.
It has been found to enhance cell-mediated immunity in humans as well as experimental animals.
As of 2009 Thymosin α1 is approved in 35 under-developed or developing countries for the treatment of Hepatitis B and C, and it is also used to boost the immune response in the treatment of other diseases.
Clinical trials suggest it may be useful in cystic fibrosis, septic shock, acute respiratory distress syndrome, peritonitis, acute cytomegalovirus infection, TB, severe acute respiratory syndrome, and lung infections in critically ill patients., and for chronic hepatitis B.
It has been studied for possible use in treating cancer (e.g. with chemotherapy).
Thymosin alpha1 Specifications
|Synthesis mode||chemic synthesis，solid phase synthesis|
|Categories||APIsPeptides; Biopharmaceuticals；Polypeptide APIs|
|Sales markets||Western Europe; Asia; North America; Central/South America|
|Selling Points||International Approvals/Standards|
Other Polypeptide APIs
|Chinese cGMP APIs|
|Product Name||GMP Certificate No.||WC|