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Levosimendan


Levosimendan is a calcium sensitizer — it increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without a rise in intracellular calcium.

Levosimendan exerts its positive inotropic effect by increasing calcium sensitivity of myocytes by binding to cardiac troponin C in a calcium-dependent manner.

It also has a vasodilatory effect, by opening adenosine triphosphate (ATP)-sensitive potassium channels in vascular smooth muscle to cause smooth muscle relaxation.

The combined inotropic and vasodilatory actions result in an increased force of contraction, decreased preload and decreased afterload. Moreover, by opening also the mitochondrial (ATP)-sensitive potassium channels in cardiomyocytes, the drug exerts a cardioprotective effect.

Levosimendan Specifications

Synthesis modechemic synthesis,solid phase synthesis
CategoriesAPIsPeptides; Biopharmaceuticals;Polypeptide APIs
Sales marketsWestern Europe; Asia; North America; Central/South America
Supplied fromChina
Selling PointsInternational Approvals/Standards

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