Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail Conus magus comprising 25 amino acids with three disulphide bonds.
Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.
Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.
Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt.
To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Ziconotide Acetate Specifications
|Synthesis mode||chemic synthesis，solid phase synthesis|
|Categories||APIsPeptides; Biopharmaceuticals；Polypeptide APIs|
|Sales markets||Western Europe; Asia; North America; Central/South America|
|Selling Points||International Approvals/Standards|
Other Polypeptide APIs
|US-DMF LIST–Polypeptide APIs|
|Product Name||US-DMF No.||WC|
|Icatibant Acetate||DMF 28496||YES|
|Octreotide Acetate||DMF 30249||YES|
|Teriparatide Acetate||DMF 32144|
|Ziconotide Acetate||DMF 33139|
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