Ziconotide Acetate

Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail Conus magus comprising 25 amino acids with three disulphide bonds.

Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.

Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.

Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt.

To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.

Ziconotide Acetate Specifications

Synthesis modechemic synthesis,solid phase synthesis
CategoriesAPIsPeptides; Biopharmaceuticals;Polypeptide APIs
Sales marketsWestern Europe; Asia; North America; Central/South America
Supplied fromChina
Selling PointsInternational Approvals/Standards

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Other Polypeptide APIs

US-DMF LIST–Polypeptide APIs
Product NameUS-DMF No.WC
BivalirudinDMF 25531YES
EptifibatideDMF 27651YES
LiraglutideDMF 29302YES
Icatibant AcetateDMF 28496YES
Octreotide AcetateDMF 30249YES
Teriparatide AcetateDMF 32144
Ziconotide AcetateDMF 33139

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