Eptifibatide Describe
CAS No.: 148031-34-9
Molecular formula: c35h49n11o9s2
English synonyms:; [3-carbamoyl-11 – {4 – [(diaminothymidine) amino] butyl} – 20 – (1h-indol-3-ylmethyl) – 1,9,12,12,15,18,21,21-hexaoxodocasahydro-7h-pyrrolo [2,1-g] [1,2,5,5,8,11,11,14,17,20] dithiahayexazacyclocricosin-17-yl] acetic acid; [(1s, 4R, 12s, 18S, 21s) – 12 – (4-carboxyl, 21s) – 12 – (4-carboxyl, 21s) – 12 – (4-carbbababa) 12 – (4-carbababacbacbacbacbacbacailoxy] acetic acid; [(1s, 4R, 12s, 18S, 21mimidamidobutyl) – 4-carb
Molecular weight: 831.96
Sequence: MPR harg Gly ASP Trp Pro Cys NH2
Eptifibatide is a cyclic heptapeptide containing 6 amino acids and 1 mercaptopropionyl (des-amino cysteinyl) residue.
An interchain disulfide bridge is formed between the cysteine amide and the mercaptopropionyl moieties. Chemically it is N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-Llysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide, cyclic (1→6)-disulfide. Eptifibatide binds to the platelet receptor glycoprotein (GP) IIb/IIIa of human platelets and inhibits platelet aggregation.
The eptifibatide peptide is produced by solution-phase peptide synthesis, and is purified by preparative reverse-phase liquid chromatography and lyophilized.
Eptifibatide Specifications
| Synthesis mode | chemic synthesis，solid phase synthesis |
|---|---|
| Categories | APIsPeptides; Biopharmaceuticals |
| Sales markets | Western Europe; Asia; North America; Central/South America |
| Supplied from | China |
| Selling Points | International Approvals/Standards |
Show more specifications
Other Polypeptide APIs Drug
| US-DMF LIST–Polypeptide APIs | ||
|---|---|---|
| Product Name | US-DMF No. | WC |
| Bivalirudin | DMF 25531 | YES |
| Eptifibatide | DMF 27651 | YES |
| Liraglutide | DMF 29302 | YES |
| Icatibant Acetate | DMF 28496 | YES |
| Octreotide Acetate | DMF 30249 | YES |
| Teriparatide Acetate | DMF 32144 | |
| Ziconotide Acetate | DMF 33139 | |
| * | * |
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