sh-polypeptide-11

sh-polypeptide-11

ALSO-CALLED-LIKE-THIS: Acidic Fibroblast growth factor, FGF1, rh-Polypeptide-11

WHAT-IT-DOES: cell-communicating ingredient

Official CosIng Information

Description: sh-polypeptide-11 is a single chain recombinant human peptide, produced by fermentation in e. coli. the starting gene is a synthesized copy of the human gene which codes for acidic fibroblast growth factor 1 used as such or adapted to the production host. it contains a maximum of 155 amino acids which may contain disulfide bonds and/or glycosylation. the protein consists of the proper sequence of the 20 standard amino acids.

Details

Sh-Polypeptide-11 is a medium sized cell signaling molecule also called Acidic Fibroblast Growth Factor. It belongs to the same group of ingredients (Growth Factors) as its better-known sister, Epidermal Growth Factor or Sh-Oligopeptide-1. As its name suggests, FGF can stimulate the growth and proliferation of fibroblast cells (VIP cells that produce among other things collagen). According to manufacturer info, it also stimulates skin regeneration, wound healing and collagen and elastin synthesis. 

As for research, we could find an in-vitro study that proved that “Recombinant FGF-1 strongly stimulated fibroblast and keratinocyte proliferation. However, the transition of this protein through the SC required an appropriate carrier system – lipid spheres.” 

It’s also good to know that slathering mitogenic (= stimulates cell proliferation) ingredients on yourself is somewhat controversial. If you are new to the “Growth Factors and skincare” topic, we have a more detailed explanation of Epidermal Growth Factor, so click here and read all about it.

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