Hyaluronic Acid Product Description

Hyaluronic acid, also known as hyaluronic acid, has a molecular formula of (C14H21NO11)n and is a disaccharide unit glycosaminoglycan composed of D-glucuronic acid and N-acetylglucosamine.
Chinese name hyaluronic acid [2] foreign name hyaluronic acid [2] alias hyaluronic acid chemical formula (C14H21NO11)n [2] CAS accession number 9004-61-9 [2] EINECS accession number 232-678-0 safety description S22; S24 /25
Main ingredient edit broadcast

Hyaluronic acid is an acidic mucopolysaccharide. In 1934, Meyer, a professor of ophthalmology at Columbia University in the United States, first isolated the substance from the bovine vitreous. With its unique molecular structure and physical and chemical properties, hyaluronic acid shows a variety of important physiological functions in the body, such as lubricating joints, regulating the permeability of blood vessel walls, regulating protein, water and electrolyte diffusion and operation, and promoting wound healing.

name edit broadcast
Hyaluronic acid, also known as hyaluronic acid, hyal- of hyaluronic acid means glass-like, bright and transparent, while uronic acid refers to uronic acid, which has nothing to do with uric acid.
Structure Editing Broadcast
The chemical structure of hyaluronic acid was elucidated in the Karl Mayer laboratory in the 1950s. Hyaluronic acid is a high-molecular polymer, which is an advanced polysaccharide composed of units D-glucuronic acid and N-acetylglucosamine. D-glucuronic acid and N-acetylglucosamine are connected by β-1,3-glycosidic bonds, and disaccharide units are connected by β-1,4-glycosidic bonds. Disaccharide units can reach as many as 25,000. The molecular weight of hyaluronic acid in the body is from 5 to 20 million dahl.
Molecular formula: (C14H21NO11)n

Main purpose editing broadcast
Biochemical drugs with high clinical value are widely used in various ophthalmic operations, such as lens implantation, corneal transplantation and anti-glaucoma surgery. It is also used to treat arthritis and accelerate wound healing. Used in cosmetics, it can play a unique role in protecting the skin. It can keep the skin moist, smooth, delicate, soft and elastic. It has the functions of anti-wrinkle, anti-wrinkle, beauty care and restoration of skin physiological functions.

The production process and technology of hyaluronic acid determine the difference in quality, so the product must be produced from the correct source in order to have therapeutic effects. Generally speaking, there are three methods of refining:

1. Animal tissue: the main raw materials are cockscomb and vitreous body of bull’s eye. Degrease and dehydrate the raw material with acetone or ethanol, soak in distilled water, filter, then treat with sodium chloride aqueous solution and chloroform solution, then add trypsin to keep warm to obtain a mixed solution, and finally treat and purify with an ion exchanger to obtain refined transparent uric acid. The extraction rate of this method is extremely low, only about 1%, and the separation process is complicated, which makes hyaluronic acid expensive, reaching 5,000 US dollars/kg, which limits its large-scale use in cosmetics.
2. Microbial fermentation: use glucose as the carbon source fermentation liquid, ferment in the culture medium for 48 hours, after the fermentation is completed, filter to remove mycelia and impurities, and then use simple operations such as alcohol precipitation to obtain high-purity products. The hyaluronic acid produced by fermentation method has the advantage that the molecular weight can be set according to the product design. The key to the fermentation method is the selection of strains, such as streptococcus and lactococcus.
3. Chemical synthesis: use natural enzyme polymerization; first use polysaccharide polymers to synthesize “hyaluronic acid oxazepine derivatives”, then add water-splitting enzymes to create complexes of derivatives and enzymes, and finally Hyaluronic acid is synthesized by removing the enzymes in the reaction solution at 90°C. The artificial synthesis method can greatly reduce the manufacturing cost of hyaluronic acid, but the structure is less pure.
   It is also a hyaluronic acid product, because of the difference in raw material sources and manufacturing technology, it has a significant impact on the effect. The concentration of the product cannot be used as a reference for product selection. Purity, molecular weight, and 3D three-dimensional structure will directly affect the water absorption effect of hyaluronic acid. Generally, the larger the molecular weight, the more complete the network structure, and the best water absorption effect. Skin care products and cosmetics are popular in the market, but many homemade hyaluronic acid is cheap, but it may not be effective. Some people even promote oral hyaluronic acid. After being absorbed by the stomach, it will be broken down into small unit molecules of sugars and amino acids. It still has to be produced in the skin and connective tissue through autosynthesis and other steps, and its effect must be compromised.
   Differences from other glycosaminoglycansEdit
   HA is very different from other glycosaminoglycans. It is not sulfated and covalently bound to proteins, but exists in free form or in the form of non-covalent complexes. Although its structure is relatively simple, its relative molecular mass is very high. Large, it is the only glycosaminoglycan that is not restricted to animal tissues and is also produced in bacteria.

Pharmaceutical Grade Products
Pharmaceutical Grade Hyaluronic Acid
Pharmaceutical Grade Hyaluronic Acid
Hyaluronic acid is the main component of connective tissues such as human interstitial cells, eye vitreous body, and joint synovial fluid. It plays important physiological functions in the body such as water retention, maintenance of extracellular space, regulation of osmotic pressure, lubrication, and promotion of cell repair. Hyaluronic acid molecules contain a large number of carboxyl groups and hydroxyl groups, forming intramolecular and intermolecular hydrogen bonds in aqueous solution, which makes it have a strong water retention effect, which can bind more than 400 times of its own water; at higher concentrations, due to The complex three-level network structure formed by the interaction between its molecules, and its aqueous solution has significant viscoelasticity. As the main component of the intercellular matrix, hyaluronic acid directly participates in the regulation of intracellular and intracellular electrolyte exchanges, and acts as a filter for physical and molecular information. Hyaluronic acid has unique physical and chemical properties and physiological functions, and has been widely used in medicine.

Hyaluronic acid can be used as a viscoelastic agent for intraocular lens implantation in ophthalmology, a filler for joint operations such as osteoarthritis and rheumatoid arthritis, and is widely used as a medium in eye drops, and it is also used to prevent postoperative Adhesion and promote the healing of skin wounds. The compound formed by the reaction of hyaluronic acid and other drugs exerts a sustained release effect on the drug, and can achieve the purpose of directional and timed release. With the development of medical science and technology, the application of hyaluronic acid in medicine will become more and more extensive.

food grade products
The content of hyaluronic acid in the human body is about 15g, which plays an important role in the physiological activities of the human body. The content of hyaluronic acid in the skin is reduced, the water retention function of the skin is weakened, it appears rough and wrinkled; the hyaluronic acid in other tissues and organs is reduced, which can lead to arthritis, arteriosclerosis, pulse disorder and brain atrophy. The reduction of hyaluronic acid in the human body produces progeria.
Cosmetology editorial broadcast

remove wrinkles
Extrusion due to age, smoking, sleeping, etc., and the traction of gravity will cause the loss of hyaluronic acid in the skin, and then gradually reduce the collagen and elastic fibers of the dermis, causing skin relaxation and facial wrinkles. By injecting hyaluronic acid Acids are effective in addressing many types of wrinkles:

1. Hyaluronic acid beauty is applied to frown lines (growth lines) and crow’s feet
   For excessively sunken frown lines, it is often impossible to obtain satisfactory results with Botox injection alone, and the effect will be better when injected with hyaluronic acid.
2. Hyaluronic acid cosmetics are applied to the corners of the mouth
   hyaluronic acid anti wrinkle
   hyaluronic acid anti wrinkle
   Although the lines produced by pouting are dynamic lines, filling the sunken lines with hyaluronic acid will have a good effect.
3. Hyaluronic acid beauty applied to nasolabial folds (nasolabial folds)
   The elimination of nasolabial folds is the most commonly used purpose of hyaluronic acid in wrinkle reduction. According to the depth of the wrinkled nose and the depth and location of the wrinkles, generally about 2 injections of macromolecular injections are required. The injection sites include the depression of the outer nose wing, nasolabial folds and the outer lower part of the lips.
4. Hyaluronic acid cosmetic application for perioral wrinkles
   Including perioral fine lines, that is, dry lines around the lips caused by long-term lack of water; including corner lines, that is, the position where the corners of the mouth pass by when drooling, some form small bracket lines, and some form large bracket lines (similar to nose lines) lip groove together).
   shaping
   Rhinoplasty: Although the development of rhinoplasty technology has reached a certain height, since hyaluronic acid injection is used for rhinoplasty, due to the advantages of hyaluronic acid rhinoplasty, no need for surgery, no pain, etc. Rhinoplasty has its challenges.
   Chin augmentation: The V-shaped face that is popular today is easy to achieve starting from the chin. It can also solve the problem of chin retraction.
   fill face
   Human aging will cause changes in the distribution of subcutaneous tissue. The temples, cheeks, eye sockets, eyebrow arches, and around the lips will all be sunken, and tear grooves will appear. Hyaluronic acid is used for facial filling including tear grooves, nasolabial folds, and puppet lines ( Women’s three “eight” lines) are popular, and the effect is relatively good.
   Lip augmentation: Generally speaking, human lips will shrink with age, wrinkles will appear, and the corners of the mouth will also sag due to aging. Hyaluronic acid filler lip augmentation has won certain praise.
5. 
   filling dents
   Hyaluronic acid can also be used to fill the pits of some acne scars, scars from trauma, surgery, and asymmetries from birth defects.
   Skin care editor broadcast
   Hyaluronic acid originally exists in the skin, which can help the skin absorb moisture from the body and the skin surface, and can also enhance the skin’s long-term water retention capacity. When hyaluronic acid absorbs water, the elastic fibers and collagen are in a moist environment, so the skin has elasticity. However, the hyaluronic acid in the skin begins to lose after the age of 25. At the age of 30, only 65% of the juvenile period is left, and at the age of 60, only 25% is left. The moisture of the skin will also be lost along with the hyaluronic acid, losing elasticity and Gloss, long-term wrinkle aging phenomenon.
   Side EffectsEdit Broadcast
   Occasionally, urticaria and pruritus of skin disease occur, the drug should be stopped and treated appropriately.
   Sometimes there is pain, swelling, and obstruction of water penetration, and occasionally edema, redness, heat, and local heavy pressure.
   As we all know, it is precisely because a substance called “hyaluronic acid” is excessively distributed in the skin of Shar-Pei dogs that it has so many wrinkles. The excess hyaluronic acid is likely due to the overactivation of a gene called “hyaluronan synthase 2”.
   When the synthetase gene is overactivated, the human body will produce corresponding enzymes to decompose and destroy the excess part, playing a certain role of “self-regulation”. Hyaluronidase dissolves excess hyaluronic acid, thereby eliminating side effects.
   PrecautionsEdit Broadcast
   Hyaluronic acid should be operated aseptically and used only once, and it is forbidden to use after the hyaluronic acid gel is damaged.
   It is not advisable to inject when the joint inflammation is obvious, and then inject hyaluronic acid gel after the inflammation is eliminated.
   In the case of joint effusion, puncture and drainage of hyaluronic acid gel outside the joint cavity will cause pain, so it must be injected into the joint cavity.
   Sometimes it causes pain, after injecting hyaluronic acid gel, the local area is treated quietly.
   When hyaluronic acid encounters bactericidal and disinfectant benzalkonium chloride, quaternary salt, etc., it will produce precipitation, and full attention should be paid when using it.
   Pregnant women and lactating women should use it with caution, those with impaired liver function should use it with caution, and those who are allergic to hyaluronic acid gel should use it with caution.
   Applicable age editor broadcast
   Hyaluronic acid is suitable for any age group that needs treatment. Hyaluronic acid injection at any age will not cause side effects. It mainly depends on whether your skin condition requires hyaluronic acid injection.
   Injection PrecautionsEdit Broadcast
6. Precautions before injection:
   Before treatment, please keep your skin clean, any cosmetics and skin care products need to be clean. It is recommended to use cleanser and astringent water to cleanse the skin. Rinse with cool water to shrink pores. It is strongly recommended that patients do not take anti-inflammatory drugs (such as aspirin, etc.) at least 3-4 days before treatment, because it may aggravate bleeding and swelling at the injection site.
7. Precautions after injection:
   After the injection treatment, please keep your face relaxed and do not make excessive facial expressions. For at least two weeks after the treatment, please avoid exposure to high heat environments (such as saunas, etc.), as it may cause the hyaluronic acid injected in the face to be broken down quickly, thereby shortening the filling effect. Do not touch or massage the injection site.
8. Adverse reactions:
   Inflammation occurs on the skin, usually accompanied by pressure pain, which lasts for about a week, and the injection site is temporarily swollen. If there is a persistent adverse reaction, please notify the injection doctor immediately.
9. Contraindications:
   Pregnant or breastfeeding women, patients under the age of 18, skin with local inflammation or infection, injection of this product while taking anticoagulant drugs, there is a great risk of swelling or bleeding. For example, taking aspirin and non-steroidal anti-inflammatory drugs. It is recommended that doctors ask beauty seekers whether they are allergic to hyaluronic acid and their past medical history before injection.
   be careful
10. Be well prepared mentally. You can choose a trustworthy medical unit or doctor to perform the operation, so as to eliminate your fear of hyaluronic acid injection, be full of confidence and sense of security, and cooperate with the doctor calmly to realize your beautiful wishes. Do not go to the doctor blindly for hyaluronic acid injection, so as not to cause adverse results.
11. Before hyaluronic acid injection, you should fully understand related knowledge and review related books. It is best to visit people who have done hyaluronic acid injection, and it is best to see the whole process of hyaluronic acid injection.
12. Before the injection of hyaluronic acid, the injection site should not have any bacterial lesions: such as folliculitis, boils, acne, acute ophthalmia, sinusitis, rhinitis, nasal vestibular boils, etc.
13. It is best to take a bath the day before hyaluronic acid injection. On the day of hyaluronic acid injection, wash off the dirt and grease on the face with soap before going to the operating table to reduce the number of bacteria as much as possible. There are other diseases in the body before hyaluronic acid injection, resulting in low resistance, which can easily lead to infection and affect wound healing after hyaluronic acid injection.
14. Women should not have hyaluronic acid injections during menstruation, so as not to cause postoperative infection.
    Distinguish between true and false products[edit]
    There are generally five types of filler materials for microplastic injections on the market that are easily confused with hyaluronic acid, including: Ogilvy (or Ingelfax), silicone oil, paraffin oil, cellulose, and collagen. There is a simple way to identify Ogilvy – some “hyaluronic acid” containing Ogilvy is mostly sold in beauty salons, and some unqualified plastic surgeons bring them to beauty salons to give injections to beauty salon guests. Injecting injections in beauty salons, the temples are in a swollen state after injections. This is the performance of Ogilvy. The streets are full of fake hyaluronic acid and collagen. Criminals have won some low consumption at low prices. The beauty seekers of ability are favored, but they are deceived, so they need to be well identified.
    Identification steps:
    Step 1: Squeeze out a drop of jelly-like substance from the needle tube and place it on white paper. If there is oil infiltration and diffusion, then this thing is definitely not hyaluronic acid, it must be silicone oil, or paraffin oil or something like that. This material, it is something that is expressly prohibited by law.
    Step 2: If it is the formation of water infiltration halo diffusion, he may be hyaluronic acid, Ogilvy (or Ingelfale), cellulose or collagen. At this time, further identification is required! The identification method is: take a drop of hyaluronic acid and put it on the left palm, and then touch it repeatedly with the pulp of the right index finger. There are sand-like crystal particles, but there is nothing else, then this is cross-linked hyaluronic acid, which can basically be confirmed to be real hyaluronic acid and can be used.
    The third identification method: Put the extruded product on a flat glass plate and observe it the next day. As a result, after overnight moisture volatilization, the remaining styling components on the glass plate were analyzed. If it’s all styling ingredients, like the “sand” particles piled up, it must be hyaluronic acid. If the “pot