Many people ask why they are called hexapeptide, some tens of gram, some hundreds of gram. In fact, this is not the same substance.
First of all, it is stated that the so-called “plant hexapeptide was originally extracted from the bacteria called Pseudomonas single-celled in the glacial mud of the Antarctic Bay.” This is not acetyl hexapeptide-8 at all. Nor does it have the ability to soothe and suppress wrinkles.
The real acetyl hexapeptide-8 is a biomimetic peptide, which is an oligopeptide composed of six amino acids that mimics the N-terminus of the SNAP-25 protein. His peptide structure is derived from a fragment of the human body’s own SNAP-25 (synaptosome-associated protein) N-terminal, and has undergone some chemical modifications. Clinical experiments have confirmed that hexapeptide is a scientifically and rationally designed anti-wrinkle polypeptide active material based on the biochemical mechanism of human skin.
SNARE is a calcium-dependent extracellular secretion that can release neurotransmitters from synaptic vesicles and reach the postsynaptic membrane through the synaptic gap, where they can interact with the corresponding receptors. Acetyl hexapeptide-8 possesses similar physiological activities as SNAP-25. It can form an ineffective combination with a part of VAMP and Syntaxin. This combination is unstable, resulting in the failure of the part of synaptic vesicles bound to it. Fusion and effective release of neurotransmitters.
At the same time, because acetyl hexapeptide-8 preemptively binds a part of VAMP and Syntaxin, the true SNARE protein assembly is reduced. As a result, neurotransmitters such as acetylcholine and catecholamines released by synaptic vesicles are reduced, and the degree of muscle contraction is weakened, thereby achieving The effect of wrinkle removal.